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Molecular Imaging Publications

 

2018:


Heilemann, G., L. Fetty, M. Blaickner, N. Nesvacil, M. Zehetmayer, D. Georg and R. Dunavoelgyi (2018). "Retina dose as a predictor for visual acuity loss in Ru-106 eye plaque brachytherapy of uveal melanomas." Radiotherapy and Oncology 127(3): 379-384.


Matzneller, P., M. Kussmann, S. Eberl, A. Maier-Salamon, W. Jäger, M. Bauer, O. Langer, M. Zeitlinger and W. Poeppl (2018). "Pharmacokinetics of the P-gp Inhibitor Tariquidar in Rats After Intravenous, Oral, and Intraperitoneal Administration." European Journal of Drug Metabolism and Pharmacokinetics 43(5): 599-606.


Goutal, S., O. Langer, S. Auvity, K. Andrieux, C. Coulon, F. Caille, P. Gervais, S. Cisternino, X. Decleves and N. Tournier (2018). "Intravenous infusion for the controlled exposure to the dual ABCB1 and ABCG2 inhibitor elacridar in nonhuman primates." Drug Delivery and Translational Research 8(3): 536-542.


Philippe, C., S. Mairinger, V. Pichler, J. Stanek, L. Nics, M. Mitterhauser, M. Hacker, T. Wanek, O. Langer and W. Wadsak (2018). "Comparison of fully-automated radiosyntheses of [(11)C]erlotinib for preclinical and clinical use starting from in target produced [(11)C]CO2 or [(11)C]CH4." EJNMMI Radiopharmacy and Chemistry 3(1): 8.


Tournier, N., B. Stieger and O. Langer (2018). "Imaging techniques to study drug transporter function in vivo." Pharmacology & Therapeutics 189: 104-122.


Mairinger, S., V. Zoufal, T. Wanek, A. Traxl, T. Filip, M. Sauberer, J. Stanek, C. Kuntner, J. Pahnke, M. Müller and O. Langer (2018). "Influence of breast cancer resistance protein and P-glycoprotein on tissue distribution and excretion of Ko143 assessed with PET imaging in mice." European Journal of Pharmaceutical Sciences 115: 212-222.


Bauer, M., A. Matsuda, B. Wulkersdorfer, C. Philippe, A. Traxl, C. Özvegy-Laczka, J. Stanek, L. Nics, E. M. Klebermass, S. Poschner, W. Jäger, I. Patik, E. Bakos, G. Szakacs, W. Wadsak, M. Hacker, M. Zeitlinger and O. Langer (2018). "Influence of OATPs on Hepatic Disposition of Erlotinib Measured With Positron Emission Tomography." Clinical Pharmacology & Therapeutics 104(1): 139-147.

 

2017:


Bauer, M., R. Karch, N. Tournier, S. Cisternino, W. Wadsak, M. Hacker, P. Marhofer, M. Zeitlinger and O. Langer (2017). "Assessment of P-Glycoprotein Transport Activity at the Human Blood Retina Barrier with (R)-C-11-Verapamil PET." Journal of Nuclear Medicine 58(4): 678-681.


Bauer, M., B. Wulkersdorfer, R. Karch, C. Philippe, W. Jäger, J. Stanek, W. Wadsak, M. Hacker, M. Zeitlinger and O. Langer (2017). "Effect of P-glycoprotein inhibition at the blood-brain barrier on brain distribution of (R)-[C-11]verapamil in elderly vs. young subjects." British Journal of Clinical Pharmacology 83(9): 1991-1999.


Denk, C., M. Wilkovitsch, P. Skrinjar, D. Svatunek, S. Mairinger, C. Kuntner, T. Filip, J. Fröhlich, T. Wanek and H. Mikula (2017). "[F-18]Fluoroalkyl azides for rapid radiolabeling and (Re)investigation of their potential towards in vivo click chemistry." Organic & Biomolecular Chemistry 15(28): 5976-5982.


Grünewald, C., M. Sauberer, T. Filip, T. Wanek, J. Stanek, S. Mairinger, S. Rollet, P. Kudejova, O. Langer, C. Schütz, M. Blaickner and C. Kuntner (2017). "On the applicability of [F-18]FBPA to predict L-BPA concentration after amino acid preloading in HuH-7 liver tumor model and the implication for liver boron neutron capture therapy." Nuclear Medicine and Biology 44: 83-89.


Heilemann, G., L. Fetty, M. Dulovits, M. Blaickner, N. Nesvacil, D. Georg and R. Dunavoelgyi (2017). "Treatment plan optimization and robustness of Ru-106 eye plaque brachytherapy using a novel software tool." Radiotherapy and Oncology 123(1): 119-124.


Kostiukhina, N., D. Georg, S. Rollet, P. Kuess, A. Sipaj, P. Andrzejewski, H. Furtado, I. Rausch, W. Lechner, E. Steiner, H. Kertesz and B. Knausl (2017). "Advanced Radiation DOSimetry phantom (ARDOS): a versatile breathing phantom for 4D radiation therapy and medical imaging." Physics in Medicine and Biology 62(20): 8136-8153.


Lassen, M. L., O. Muzik, T. Beyer, M. Hacker, C. N. Ladefoged, J. Cal-Gonzalez, W. Wadsak, I. Rausch, O. Langer and M. Bauer (2017). "Reproducibility of Quantitative Brain Imaging Using a PET-Only and a Combined PET/MR System." Frontiers in Neuroscience 11.


Matsuda, A., R. Karch, M. Bauer, A. Traxl, M. Zeitlinger and O. Langer (2017). "A Prediction Method for P-glycoprotein-Mediated Drug-Drug Interactions at the Human Blood-Brain Barrier From Blood Concentration-Time Profiles, Validated With PET Data." Journal of Pharmaceutical Sciences 106(9): 2780-2786.


Osborne, D. R., C. Kuntner, S. Berr and D. Stout (2017). "Guidance for Efficient Small Animal Imaging Quality Control." Molecular Imaging and Biology 19(4): 485-498.


Schmitz, T. and M. Blaickner (2017). "Adaption of a PIN-diode detector as an online neutron monitor for the thermal column of the TRIGA research reactor." Applied Radiation and Isotopes 128: 142-147.


Steffen, J., M. Krohn, C. Schwitlick, T. Bruning, K. Paarmann, C. U. Pietrzik, H. Biverstal, B. Jansone, O. Langer and J. Pahnke (2017). "Expression of endogenous mouse APP modulates beta-amyloid deposition in hAPP-transgenic mice." Acta Neuropathologica Communications 5.


Tournier, N., S. Goutal, S. Auvity, A. Traxl, S. Mairinger, T. Wanek, O. B. Helal, I. Buvat, M. Soussan, F. Caille and O. Langer (2017). "Strategies to Inhibit ABCB1-and ABCG2-Mediated Efflux Transport of Erlotinib at the Blood-Brain Barrier: A PET Study on Nonhuman Primates." Journal of Nuclear Medicine 58(1): 117-122.


Traxl, A., T. Beikbaghban, T. Wanek, K. Kryeziu, C. Pirker, S. Mairinger, J. Stanek, T. Filip, M. Sauberer, C. Kuntner, W. Berger and O. Langer (2017). "[C-11]Erlotinib PET cannot detect acquired erlotinib resistance in NSCLC tumor xenografts in mice." Nuclear Medicine and Biology 52: 7-15.


Traxl, A., K. Komposch, E. Glitzner, T. Wanek, S. Mairinger, O. Langer and M. Sibilia (2017). "Hepatocyte-Specific Deletion of EGFR in Mice Reduces Hepatic Abcg2 Transport Activity Measured by [C-11]erlotinib and Positron Emission Tomography." Drug Metabolism and Disposition 45(10): 1093-1100.


Yang, C. T., K. K. Ghosh, P. Padmanabhan, O. Langer, J. Liu, C. Halldin and B. Z. Gulyás (2017). "PET probes for imaging pancreatic islet cells." Clinical and Translational Imaging 5(6): 507-523.

 

2016:


Bauer, M., M. Blaickner, C. Philippe, W. Wadsak, M. Hacker, M. Zeitlinger and O. Langer (2016). "Whole-Body Distribution and Radiation Dosimetry of C-11-Elacridar and C-11-Tariquidar in Humans." Journal of Nuclear Medicine 57(8): 1265-1268.


Bauer, M., K. Römermann, R. Karch, B. Wulkersdorfer, J. Stanek, C. Philippe, A. Maier-Salamon, H. Haslacher, C. Jungbauer, W. Wadsak, W. Jäger, W. Löscher, M. Hacker, M. Zeitlinger and O. Langer (2016). "Pilot PET Study to Assess the Functional Interplay Between ABCB1 and ABCG2 at the Human Blood-Brain Barrier." Clinical Pharmacology & Therapeutics 100(2): 131-141.
Bechet, S., R. Versaci, S. Rollet, V. Olsovcova, A. Fajstavr, M. Zakova and D. Margarone (2016). "Radiation protection of a proton beamline at ELI-Beamlines." Journal of Instrumentation 11(12): C12019.


Dallas, S., L. Salphati, D. Gomez-Zepeda, T. Wanek, L. F. Chen, X. Y. Chu, J. Kunta, M. Mezler, M. C. Menet, S. Chasseigneaux, X. Decleves, O. Langer, E. Pierre, K. DiLoreto, C. Hoft, L. Laplanche, J. Pang, T. Pereira, C. Andonian, D. Simic, A. Rode, J. Yabut, X. L. Zhang and N. Scheer (2016). "Generation and Characterization of a Breast Cancer Resistance Protein Humanized Mouse Model." Molecular Pharmacology 89(5): 492-504.


Denk, C., D. Svatunek, S. Mairinger, J. Stanek, T. Filip, D. Matscheko, C. Kuntner, T. Wanek and H. Mikula (2016). "Design, Synthesis, and Evaluation of a Low-Molecular-Weight C-11-Labeled Tetrazine for Pretargeted PET Imaging Applying Bioorthogonal in Vivo Click Chemistry." Bioconjugate Chemistry 27(7): 1707-1712.


Langer, O. (2016). "Use of PET Imaging to Evaluate Transporter-Mediated Drug-Drug Interactions." Journal of Clinical Pharmacology 56: S143-S156.


Wanek, T., E. Halilbasic, M. Visentin, S. Mairinger, K. Römermann, B. Stieger, C. Kuntner, M. Müller, O. Langer and M. Trauner (2016). "Influence of 24-Nor-Ursodeoxycholic Acid on Hepatic Disposition of [F-18]Ciprofloxacin, a Positron Emission Tomography Study in Mice." Journal of Pharmaceutical Sciences 105(1): 106-112.


Wanek, T., K. Kreis, P. Krizkova, A. Schweifer, C. Denk, J. Stanek, S. Mairinger, T. Filip, M. Sauberer, P. Edelhofer, A. Traxl, V. E. Muchitsch, K. Mereiter, F. Hammerschmidt, C. E. Cass, V. L. Damaraju, O. Langer and C. Kuntner (2016). "Synthesis and preclinical characterization of 1-(6 '-deoxy-6 '-[F-18]fluoro-beta-D-allofuranosyl)-2-nitroimidazole beta-6 '-[F-18]FAZAL) as a positron emission tomography radiotracer to assess tumor hypoxia." Bioorganic & Medicinal Chemistry 24(21): 5326-5339.


Wingelhofer, B., K. Kreis, S. Mairinger, V. Muchitsch, J. Stanek, T. Wanek, O. Langer and C. Kuntner (2016). "Preloading with L-BPA, L -tyrosine and L-DOPA enhances the uptake of [F-18]FBPA in human and mouse tumour cell lines." Applied Radiation and Isotopes 118: 67-72.

 

2015:


Bauer, M., R. Karch, M. Zeitlinger, C. Philippe, K. Römermann, J. Stanek, A. Maier-Salamon, W. Wadsak, W. Jäger, M. Hacker, M. Müller and O. Langer (2015). "Approaching complete inhibition of P-glycoprotein at the human blood-brain barrier: an (R)-[C-11]verapamil PET study." Journal of Cerebral Blood Flow and Metabolism 35(5): 743-746.


Haeusler, D., C. Kuntner, L. Nies, M. Savli, M. Zeilinger, T. Wanek, P. Karagiannis, R. R. Lanzenberger, O. Langer, K. Shanab, H. Spreitzer, W. Wadsak, M. Hacker and M. Mitterhauser (2015). "[F-18]FE@SUPPY: a suitable PET tracer for the adenosine A3 receptor? An in vivo study in rodents." European Journal of Nuclear Medicine and Molecular Imaging 42(5): 741-749.


Heilemann, G., N. Nesvacil, M. Blaickner, N. Kostiukhina and D. Georg (2015). "Multidimensional dosimetry of Ru-106 eye plaques using EBT3 films and its impact on treatment planning." Medical Physics 42(10): 5798-5808.


Layer, T., M. Blaickner, B. Knäusl, D. Georg, J. Neuwirth, R. P. Baum, C. Schuchardt, S. Wiessalla and G. Matz (2015). "PET image segmentation using a Gaussian mixture model and Markov random fields." EJNMMI Physics 2(1): 9.


Mairinger, S., J. Stanek, T. Wanek, O. Langer and C. Kuntner (2015). "Automated electrophilic radiosynthesis of [F-18]FBPA using a modified nucleophilic GE TRACERlab FXFDG." Applied Radiation and Isotopes 104: 124-127.


Neuwirth, J., T. Layer, M. Blaickner, W. Birkfellner and A. Staudenherz (2015). "Investigation of Reconstruction Algorithms by Means of Quantitative PET/CT Phantom Studies with a Focus on Evaluation Strategies A PET/CT Phantom Study." International Journal of Life Science and Medical Research 5(2): 7-15.


Peters, T., C. Grünewald, M. Blaickner, M. Ziegner, C. Schutz, D. Iffland, G. Hampel, T. Nawroth and P. Langguth (2015). "Cellular uptake and in vitro antitumor efficacy of composite liposomes for neutron capture therapy." Radiation Oncology 10.


Roehrbacher, F., J. P. Bankstahl, M. Bankstahl, T. Wanek, J. Stanek, M. Sauberer, J. Müllauer, T. Schroettner, O. Langer and C. Kuntner (2015). "Development and performance test of an online blood sampling system for determination of the arterial input function in rats." EJNMMI Physics 2(1): 1.


Sander, K., E. Galante, T. Gendron, E. Yiannaki, N. Patel, T. L. Kalber, A. Badar, M. Robson, S. P. Johnson, F. Bauer, S. Mairinger, J. Stanek, T. Wanek, C. Kuntner, T. Kottke, L. Weizel, D. Dickens, K. Erlandsson, B. F. Hutton, M. F. Lythgoe, H. Stark, O. Langer, M. Koepp and E. Arstad (2015). "Development of Fluorine-18 Labeled Metabolically Activated Tracers for Imaging of Drug Efflux Transporters with Positron Emission Tomography." Journal of Medicinal Chemistry 58(15): 6058-6080.


Schmitz, T., N. Bassler, M. Blaickner, M. Ziegner, M. C. Hsiao, Y. H. Liu, H. Koivunoro, I. Auterinen, T. Seren, P. Kotiluoto, H. Palmans, P. Sharpe, P. Langguth and G. Hampel (2015). "The alanine detector in BNCT dosimetry: Dose response in thermal and epithermal neutron fields." Medical Physics 42(1): 400-411.


Stanek, J., S. Mairinger, T. Wanek, C. Kuntner, M. Müller and O. Langer (2015). "Automated radiosynthesis of [F-18]ciprofloxacin." Applied Radiation and Isotopes 99: 133-137.


Traxl, A., T. Wanek, S. Mairinger, J. Stanek, T. Filip, M. Sauberer, M. Müller, C. Kuntner and O. Langer (2015). "Breast Cancer Resistance Protein and P-Glycoprotein Influence In Vivo Disposition of C-11-Erlotinib." Journal of Nuclear Medicine 56(12): 1930-1936.


Wanek, T., K. Römermann, S. Mairinger, J. Stanek, M. Sauberer, T. Filip, A. Traxl, C. Kuntner, J. Pahnke, F. Bauer, T. Erker, W. Löscher, M. Müller and O. Langer (2015). "Factors Governing P-Glycoprotein-Mediated Drug-Drug Interactions at the Blood-Brain Barrier Measured with Positron Emission Tomography." Molecular Pharmaceutics 12(9): 3214-3225.


Wanek, T., A. Traxl, J. P. Bankstahl, M. Bankstahl, M. Sauberer, O. Langer and C. Kuntner (2015). "[F-18]FDG is not transported by P-glycoprotein and breast cancer resistance protein at the rodent blood-brain barrier." Nuclear Medicine and Biology 42(7): 585-589.

 

2014:


Bauer, M., R. Karch, M. Zeitlinger, J. Liu, M. J. Koepp, M. C. Asselin, S. M. Sisodiya, J. A. Hainfellner, W. Wadsak, M. Mitterhauser, M. Müller, E. Pataraia and O. Langer (2014). "In vivo P-glycoprotein function before and after epilepsy surgery." Neurology 83(15): 1326-1331.


Blaickner, M. and R. P. Baum (2014). "Relevance of PET for pretherapeutic prediction of doses in peptide receptor radionuclide therapy." PET Clinics 9(1): 99-112.


Denk, C., D. Svatunek, T. Filip, T. Wanek, D. Lumpi, J. Fröhlich, C. Kuntner and H. Mikula (2014). "Development of a F-18-Labeled Tetrazine with Favorable Pharmacokinetics for Bioorthogonal PET Imaging." Angewandte Chemie-International Edition 53(36): 9655-9659.


Kuntner, C. (2014). "Kinetic modeling in pre-clinical positron emission tomography." Zeitschrift für Medizinische Physik 24(4): 274-285.

 

Kuntner, C. and D. Stout (2014). "Quantitative preclinical PET imaging: opportunities and challenges." Frontiers in Physics 2(12).


Kvaternik, H., T. Wanek, F. Hammerschmidt, I. Zolle, R. Aigner and C. Kuntner (2014). "Radiosynthesis of [I-124]Iodometomidate and Biological Evaluation Using Small-Animal PET." Molecular Imaging and Biology 16(3): 317-321.


Pahnke, J., O. Langer and M. Krohn (2014). "Alzheimer's and ABC transporters - new opportunities for diagnostics and treatment." Neurobiology of Disease 72: 54-60.


Ruhm, W., V. Mares, C. Pioch, S. Agosteo, A. Endo, M. Ferrarini, I. Rakhno, S. Rollet, D. Satoh and H. Vincke (2014). "Comparison of Bonner sphere responses calculated by different Monte Carlo codes at energies between 1 MeV and 1 GeV - Potential impact on neutron dosimetry at energies higher than 20 MeV." Radiation Measurements 67: 24-34.


Stieger, B., J. D. Unadkat, B. Prasad, O. Langer and H. Gali (2014). "Role of (drug) transporters in imaging in health and disease." Drug Metabolism and Disposition 42(12): 2007-2015.


Wulkersdorfer, B., T. Wanek, M. Bauer, M. Zeitlinger, M. Müller and O. Langer (2014). "Using Positron Emission Tomography to Study Transporter-Mediated Drug-Drug Interactions in Tissues." Clinical Pharmacology & Therapeutics 96(2): 206-213.


Ziegner, M., T. Schmitz, R. Khan, M. Blaickner, H. Palmans, P. Sharpe, G. Hampel and H. Böck (2014). "Confirmation of a realistic reactor model for BNCT dosimetry at the TRIGA Mainz." Medical Physics 41(11).

2013:


Bankstahl, J. P., M. Bankstahl, K. Römermann, T. Wanek, J. Stanek, A. D. Windhorst, M. Fedrowitz, T. Erker, M. Müller, W. Löscher, O. Langer and C. Kuntner (2013). "Tariquidar and Elacridar Are Dose-Dependently Transported by P-Glycoprotein and Bcrp at the Blood-Brain Barrier: A Small-Animal Positron Emission Tomography and In Vitro Study." Drug Metabolism and Disposition 41(4): 754-762.


Bauer, M., M. Zeitlinger, D. Todorut, M. Böhmdorfer, M. Müller, O. Langer and W. Jäger (2013). "Pharmacokinetics of single ascending doses of the P-glycoprotein inhibitor tariquidar in healthy subjects." Pharmacology 91(1-2): 12-19.


Blaickner, M. and J. Neuwirth (2013). "Measurements of occupational and patient exposure as well as image quality for two C-arms." Radiation Protection Dosimetry 155(4): 451-458.


Feldmann, M., M. C. Asselin, J. Liu, S. N. Wang, A. McMahon, J. Anton-Rodriguez, M. Walker, M. Symms, G. Brown, R. Hinz, J. Matthews, M. Bauer, O. Langer, M. Thom, T. Jones, C. Vollmar, J. S. Duncan, S. M. Sisodiya and M. J. Koepp (2013). "P-glycoprotein expression and function in patients with temporal lobe epilepsy: a case-control study." Lancet Neurology 12(8): 777-785.


Müllauer, J., R. Karch, J. P. Bankstahl, M. Bankstahl, J. Stanek, T. Wanek, S. Mairinger, M. Müller, W. Löscher, O. Langer and C. Kuntner (2013). "Assessment of cerebral P-glycoprotein expression and function with PET by combined [C-11]inhibitor and [C-11]substrate scans in rats." Nuclear Medicine and Biology 40(6): 755-763.


Müllauer, J., R. Willimayer, A. L. Goertzen, T. Wanek, O. Langer, W. Birkfellner and C. Kuntner (2013). "18F, 11C and 68Ga in small animal PET imaging. Evaluation of partial volume correction methods." Nuklearmedizin 52(6): 250-261.


Philippe, C., L. Nics, M. Zeilinger, C. Kuntner, T. Wanek, S. Mairinger, K. Shanab, H. Spreitzer, H. Viernstein, W. Wadsak and M. Mitterhauser (2013). "Preclinical in vitro & in vivo evaluation of [C-11]SNAP-7941-the first PET tracer for the melanin concentrating hormone receptor 1." Nuclear Medicine and Biology 40(7): 919-925.


Römermann, K., T. Wanek, M. Bankstahl, J. P. Bankstahl, M. Fedrowitz, M. Müller, W. Löscher, C. Kuntner and O. Langer (2013). "(R)-[C-11]verapamil is selectively transported by murine and human P-glycoprotein at the blood-brain barrier, and not by MRP1 and BCRP." Nuclear Medicine and Biology 40(7): 873-878.


Stout, D., S. S. Berr, A. LeBlanc, J. D. Kalen, D. Osborne, J. Price, W. Schiffer, C. Kuntner and J. Wall (2013). "Guidance for Methods Descriptions Used in Preclinical Imaging Papers." Molecular Imaging 12(7).


Wanek, T., S. Mairinger and O. Langer (2013). "Radioligands targeting P-glycoprotein and other drug efflux proteins at the blood-brain barrier." Journal of Labelled Compounds & Radiopharmaceuticals 56(3-4): 68-77.

2012:


Bauer, F., T. Wanek, S. Mairinger, J. Stanek, M. Sauberer, C. Kuntner, Z. Parveen, P. Chiba, M. Müller, O. Langer and T. Erker (2012). "Interaction of HM30181 with P-glycoprotein at the murine blood-brain barrier assessed with positron emission tomography." European Journal of Pharmacology 696(1-3): 18-27.


Bauer, M., M. Zeitlinger, R. Karch, P. Matzneller, J. Stanek, W. Jäger, M. Böhmdorfer, W. Wadsak, M. Mitterhauser, J. P. Bankstahl, W. Löscher, M. Koepp, C. Kuntner, M. Müller and O. Langer (2012). "Pgp-Mediated Interaction Between (R)-[C-11]Verapamil and Tariquidar at the Human Blood-Brain Barrier: A Comparison With Rat Data." Clinical Pharmacology & Therapeutics 91(2): 227-233.


Blaickner, M., J. V. Kratz, S. Minouchehr, G. Otto, H. Schmidberger, C. Schutz, L. Vogtlander, B. Wortmann and G. Hampel (2012). "Dosimetric feasibility study for an extracorporeal BNCT application on liver metastases at the TRIGA Mainz." Applied Radiation and Isotopes 70(1): 139-143.


Mairinger, S., J. P. Bankstahl, C. Kuntner, K. Römermannd, M. Bankstahl, T. Wanek, J. Stanek, W. Löscher, M. Müllner, T. Erker and O. Langer (2012). "The antiepileptic drug mephobarbital is not transported by P-glycoprotein or multidrug resistance protein 1 at the blood-brain barrier: A positron emission tomography study." Epilepsy Research 100(1-2): 93-103.


Mairinger, S., T. Wanek, C. Kuntner, Y. Doenmez, S. Strommer, J. Stanek, E. Capparelli, P. Chiba, M. Müller, N. A. Colabufo and O. Langer (2012). "Synthesis and preclinical evaluation of the radiolabeled P-glycoprotein inhibitor [C-11]MC113." Nuclear Medicine and Biology 39(8): 1219-1225.


Müllauer, J., C. Kuntner, M. Bauer, J. P. Bankstahl, M. Müller, R. A. Voskuyl, O. Langer and S. Syvänen (2012). "Pharmacokinetic modeling of P-glycoprotein function at the rat and human blood-brain barriers studied with (R)-[C-11]verapamil positron emission tomography." EJNMMI Research 2.


Rollet, S., M. Angelone, G. Magrin, M. Marinelli, E. Milani, M. Pillon, G. Prestopino, C. Verona and G. Verona-Rinati (2012). "A Novel Microdosimeter Based Upon Artificial Single Crystal Diamond." IEEE Transactions on Nuclear Science 59(5): 2409-2415.


Wanek, T., C. Kuntner, J. P. Bankstahl, M. Bankstahl, J. Stanek, M. Sauberer, S. Mairinger, S. Strommer, V. Wacheck, W. Löscher, T. Erker, M. Müller and O. Langer (2012). "A comparative small-animal PET evaluation of [C-11]tariquidar, [C-11]elacridar and (R)-[C-11]verapamil for detection of P-glycoprotein-expressing murine breast cancer." European Journal of Nuclear Medicine and Molecular Imaging 39(1): 149-159.


Wanek, T., C. Kuntner, J. P. Bankstahl, S. Mairinger, M. Bankstahl, J. Stanek, M. Sauberer, T. Filip, T. Erker, M. Müller, W. Löscher and O. Langer (2012). "A novel PET protocol for visualization of breast cancer resistance protein function at the blood-brain barrier." Journal of Cerebral Blood Flow and Metabolism 32(11): 2002-2011.

 

2011:


Bankstahl, J. P., M. Bankstahl, C. Kuntner, J. Stanek, T. Wanek, M. Meier, X. Q. Ding, M. Müller, O. Langer and W. Löscher (2011). "A Novel Positron Emission Tomography Imaging Protocol Identifies Seizure-Induced Regional Overactivity of P-Glycoprotein at the Blood-Brain Barrier." Journal of Neuroscience 31(24): 8803-8811.


Dörner, B., C. Kuntner, J. P. Bankstahl, T. Wanek, M. Bankstahl, J. Stanek, J. Müllauer, F. Bauer, S. Mairinger, W. Löscher, D. W. Miller, P. Chiba, M. Müller, T. Erker and O. Langer (2011). "Radiosynthesis and in vivo evaluation of 1-[F-18]fluoroelacridar as a positron emission tomography tracer for P-glycoprotein and breast cancer resistance protein." Bioorganic & Medicinal Chemistry 19(7): 2190-2198.


Fuereder, T., T. Wanek, P. Pflegerl, A. Jaeger-Lansky, D. Hoeflmayer, S. Strommer, C. Kuntner, F. Wrba, J. Werzowa, M. Hejna, M. Müller, O. Langer and V. Wacheck (2011). "Gastric Cancer Growth Control by BEZ235 In Vivo Does Not Correlate with PI3K/mTOR Target Inhibition but with [F-18]FLT Uptake." Clinical Cancer Research 17(16): 5322-5332.


Kuntner, C., T. Wanek, M. Hoffer, D. Dangl, M. Hornof, H. Kvaternik and O. Langer (2011). "Radiosynthesis and Assessment of Ocular Pharmacokinetics of I-124-Labeled Chitosan in Rabbits Using Small-Animal PET." Molecular Imaging and Biology 13(2): 222-226.


Leitner, I., J. Nemeth, T. Feurstein, A. Abrahim, P. Matzneller, H. Lagler, T. Erker, O. Langer and M. Zeitlinger (2011). "The third-generation P-glycoprotein inhibitor tariquidar may overcome bacterial multidrug resistance by increasing intracellular drug concentration." Journal of Antimicrobial Chemotherapy 66(4): 834-839.


Mairinger, S., T. Erker, M. Müller and O. Langer (2011). "PET and SPECT Radiotracers to Assess Function and Expression of ABC Transporters In Vivo." Current Drug Metabolism 12(8): 774-792.


Schmitz, T., M. Blaickner, M. Ziegner, N. Bassler, C. Grunewald, J. V. Kratz, C. Schutz, P. Langguth, P. Sharpe, H. Palmans, M. H. Holzscheiter, G. Otto and G. Hampel (2011). "Dose determination using alanine detectors in a mixed neutron and gamma field for boron neutron capture therapy of liver malignancies." Acta Oncologica 50(6): 817-822.


Wagner, C. C. and O. Langer (2011). "Approaches using molecular imaging technology - use of PET in clinical microdose studies." Advanced Drug Delivery Reviews 63(7): 539-546.

 

2010:


Bauer, F., C. Kuntner, J. P. Bankstahl, T. Wanek, M. Bankstahl, J. Stanek, S. Mairinger, B. Dörner, W. Löscher, M. Müller, T. Erker and O. Langer (2010). "Synthesis and in vivo evaluation of [11C]tariquidar, a positron emission tomography radiotracer based on a third-generation P-glycoprotein inhibitor." Bioorganic & Medicinal Chemistry 18(15): 5489-5497.


Bauer, M., R. Karch, F. Neumann, C. C. Wagner, K. Kletter, M. Müller, W. Löscher, M. Zeitlinger and O. Langer (2010). "Assessment of regional differences in tariquidar-induced P-glycoprotein modulation at the human blood-brain barrier." Journal of Cerebral Blood Flow and Metabolism 30(3): 510-515.


Kesner, A. L. and C. Kuntner (2010). "A new fast and fully automated software based algorithm for extracting respiratory signal from raw PET data and its comparison to other methods." Medical Physics 37(10): 5550-5559.


Kuntner, C., J. P. Bankstahl, M. Bankstahl, J. Stanek, T. Wanek, G. Stundner, R. Karch, R. Brauner, M. Meier, X. Ding, M. Müller, W. Löscher and O. Langer (2010). "Dose-response assessment of tariquidar and elacridar and regional quantification of P-glycoprotein inhibition at the rat blood-brain barrier using (R)-[(11)C]verapamil PET." European Journal of Nuclear Medicine and Molecular Imaging 37(5): 942-953.


Löscher, W. and O. Langer (2010). "Imaging of P-glycoprotein function and expression to elucidate mechanisms of pharmacoresistance in epilepsy." Current Topics in Medicinal Chemistry 10(17): 1785-1791.


Mairinger, S., O. Langer, C. Kuntner, T. Wanek, J. P. Bankstahl, M. Bankstahl, J. Stanek, B. Dörner, F. Bauer, C. Baumgartner, W. Löscher, T. Erker and M. Müller (2010). "Synthesis and in vivo evaluation of the putative breast cancer resistance protein inhibitor [11C]methyl 4-((4-(2-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl)phenyl)amino-car bonyl)-2-(quinoline-2-carbonylamino)benzoate." Nuclear Medicine and Biology 37(5): 637-644.


Schmitz, T., M. Blaickner, C. Schutz, N. Wiehl, J. V. Kratz, N. Bassler, M. H. Holzscheiter, H. Palmans, P. Sharpe, G. Otto and G. Hampel (2010). "Dose calculation in biological samples in a mixed neutron-gamma field at the TRIGA reactor of the University of Mainz." Acta Oncologica 49(7): 1165-1169

2009:


Cejka, D., C. Kuntner, M. Preusser, M. Fritzer-Szekeres, B. J. Fueger, S. Strommer, J. Werzowa, T. Fuereder, T. Wanek, M. Zsebedics, M. Müller, O. Langer and V. Wacheck (2009). "FDG uptake is a surrogate marker for defining the optimal biological dose of the mTOR inhibitor everolimus in vivo." British Journal of Cancer 100(11): 1739-1745.


Dimou, E., J. Booij, M. Rodrigues, H. Prosch, J. Attems, P. Knoll, B. Zajicek, R. Dudczak, G. Mostbeck, C. Kuntner, O. Langer, T. Bruecke and S. Mirzaei (2009). "Amyloid PET and MRI in Alzheimer's disease and mild cognitive impairment." Current Alzheimer Research 6(3): 312-319.


Dörner, B., C. Kuntner, J. P. Bankstahl, M. Bankstahl, J. Stanek, T. Wanek, G. Stundner, S. Mairinger, W. Löscher, M. Müller, O. Langer and T. Erker (2009). "Synthesis and small-animal positron emission tomography evaluation of [11C]-elacridar as a radiotracer to assess the distribution of P-glycoprotein at the blood-brain barrier." Journal of Medicinal Chemistry 52(19): 6073-6082.


Hampel, G., B. Wortmann, M. Blaickner, J. Knorr, J. V. Kratz, A. Lizon Aguilar, S. Minouchehr, S. Nagels, G. Otto, H. Schmidberger, C. Schutz and L. Vogtlander (2009). "Irradiation facility at the TRIGA Mainz for treatment of liver metastases." Applied Radiation and Isotopes 67(7-8 Suppl): S238-241.


Kuntner, C., A. L. Kesner, M. Bauer, R. Kremslehner, T. Wanek, M. Mandler, R. Karch, J. Stanek, T. Wolf, M. Müller and O. Langer (2009). "Limitations of small animal PET imaging with [18F]FDDNP and FDG for quantitative studies in a transgenic mouse model of Alzheimer's disease." Molecular Imaging and Biology 11(4): 236-240.


Reiner, D., M. Blaickner and F. Rattay (2009). "Discrete beta dose kernel matrices for nuclides applied in targeted radionuclide therapy (TRT) calculated with MCNP5." Medical Physics 36(11): 4890-4896.


Suckow, C., C. Kuntner, P. Chow, R. Silverman, A. Chatziioannou and D. Stout (2009). "Multimodality rodent imaging chambers for use under barrier conditions with gas anesthesia." Molecular Imaging and Biology 11(2): 100-106

2008:


Bankstahl, J. P., C. Kuntner, A. Abrahim, R. Karch, J. Stanek, T. Wanek, W. Wadsak, K. Kletter, M. Müller, W. Löscher and O. Langer (2008). "Tariquidar-induced P-glycoprotein inhibition at the rat blood-brain barrier studied with (R)-11C-verapamil and PET." Journal of Nuclear Medicine 49(8): 1328-1335.


Berndt, U., C. Stanetty, T. Wanek, C. Kuntner, J. Stanek, M. Berger, M. Bauer, G. Henriksen, H. J. Wester, H. Kvaternik, P. Angelberger and C. Noe (2008). "Synthesis of a [(18)F]fluorobenzothiazole as potential amyloid imaging agent." Journal of Labelled Compounds & Radiopharmaceuticals 51(3-4): 137-145.


Blaickner, M. and P. Kindl (2008). "Diversification of existing reference phantoms in nuclear medicine: Calculation of specific absorbed fractions for 21 mathematical phantoms and validation through dose estimates resulting from the administration of (18)F-FDG." Cancer Biotherapy & Radiopharmaceuticals 23(6): 767-782.


Lechner, A., M. Blaickner, S. Gianolini, K. Poljanc, H. Aiginger and D. Georg (2008). "Targeted radionuclide therapy: theoretical study of the relationship between tumour control probability and tumour radius for a 32P/33P radionuclide cocktail." Physics in Medicine and Biology 53(7): 1961-1974.

2007:


Lartizien, C., C. Kuntner, A. L. Goertzen, A. C. Evans and A. Reilhac (2007). "Validation of PET-SORTEO Monte Carlo simulations for the geometries of the MicroPET R4 and Focus 220 PET scanners." Physics in Medicine and Biology 52(16): 4845-4862.


Mitterhauser, M., S. Toegel, W. Wadsak, R. R. Lanzenberger, L. K. Mien, C. Kuntner, T. Wanek, H. Eidherr, D. E. Ettlinger, H. Viernstein, R. Kluger, R. Dudczak and K. Kletter (2007). "Pre vivo, ex vivo and in vivo evaluations of [68Ga]-EDTMP." Nuclear Medicine and Biology 34(4): 391-397.