Researcher Profile

Dr. Mag. Günter Brader

Dr. Mag. Brader

Function

Senior Scientist

Center

Health & Environment

Business Unit

Bioresources

E-Mail

Guenter.Brader(at)ait.ac.at

Phone

+43 50550 4669

Fax

+43 50550 3666

Address

UFT, Konrad-Lorenz-Straße 24, 3430 Tulln

Career

Area: Resource Exploitation and Management

Field: Exploitation of Biological Resources

Main Research: Plant-microbe interactions and in the exploitation of bacterial resources

Experience:

Dr. Günter Brader finished his studies in biology at the University of Vienna in 1992 and received his PhD at the Institute of Botany of the University of Vienna with studies on the "Compounds of Rutaceae and their Biological Activity against Spodoptera littoralis" in 1997. After gaining post doc experience in the field of molecular biology and plant-microbe interactions he was appointed to be "Docent in Plant Molecular Biology" by the Helsinki University in 2004.
 
Günter Brader is author of 43 peer reviewed publications with a total number of citations of 2934 and an h-index of 22. He has been (Co)-Supervisor of five finished PhD studies and is now project leader and senior scientist and project leader at the Austrian Institute of Technology (AIT) with currently five PhD students.
 
The reasearch intersts of Günter Brader are in the field of plant-microbe interactions and in understanding and exploiting bacterial mechanisms and signaling to interact with its host plants and with each other. During his work at the Institute of Biotechnology and at the Division of Genetics at the University of Helsinki he studied signal transduction and  interactions between plants and pathogens using Arabidopsis thaliana and potato  and Pectobacterium carotovorum, Pseudomonas syringae and Alternaria brassicicola as model systems. He worked on the analysis of glucosinolates, phytoalexins and plant and bacterial signal compounds using techniques in metabolic profiling and molecular biology, especially in transcriptome and comparative genome analysis. He has established the bacteria & plant metabolite profiling core facilities at the Viikki Biocenter using GC-MS, HPLC and LC-MS (Q-TOF) allowing hormone profiling, profiling of polar small metabolites and peptides, secondary plant metabolites and bacterial signaling components, which became later part of the Biocentrum Helsinki “Metabolomics Unit” core facility.
 
Currently, Günter Brader is studying the genomic and transcriptomic variance of bacteria interacting with plants to understand and to exploit their potential. This includes also metagenomic approaches for organisms, which are difficult or so far impossible to cultivate. Current projects include the studies of plant pathogenic phytoplasmas, which are transmitted in complex epidemiological cycles. Genome and transcriptome analysis allows not only academic understanding of these bacterial groups, but also opens up methodologies to control phytoplasma diseases. Important beneficial bacteria involved in the control of plant diseases are a number of members of the Bacilli. Especially due to endospore formation, high stability, production of important enzymes this groups is highly interesting for the industry including the bio-pesticides market. Systematic study of the genetic potential to produce different types of secondary metabolites should allow an optimization of exploitation of Bacilli for applications in agriculture, as secondary metabolites of Bacilli not only include metabolites with direct antimicrobial activity, but also play roles in biofilm formation on root surfaces, bacterial signaling and community establishment, all prerequisites for successful establishment and subsequent biocontrol functions. Bacilli possess a variety of secondary metabolite gene clusters responsible for remarkable diverse number of especially polyketides and lipopeptides and by genome mining we detected a number of so far undescribed metabolite clusters. As even in this relatively well studied group a number of gene clusters encoding for hitherto undescribed metabolites were found, our results highlighted the unexplored potential of secondary metabolite production in bacteria, both in cultivable and so far uncultivable, which can be explored for various applications.

  • 1993-1998: Research Assistant
    Institute of Botany, University of Vienna / Austria
  • 1998-2001: Post Doc Fellow
    Institute of Biotechnology, University of Helsinki / Finland
  • 2002-2009: Researcher, Group Leader and University Lecturer
    Division of Genetics, University of Helsinki / Finland
  • 2008-2009: Guest Professor
    Institute of Botany / Austria
  • 2008-2010: Researcher
    Austrian Institute of Technology / Austria
  • 2010-2015: Scientist
    Austrian Institute of Technology / Austria
  • 2015-: Senior Scientist and Group Leader
    Austrian Institute of Technology / Austria

Publications

  • Jasmonate-Dependent Induction of Indole Glucosinolates in Arabidopsis by Culture Filtrates of the Nonspecific Pathogen Erwinia carotovora.
    Author(s): Brader, G., Tas, E., Palva, E.T.
    Journal: Plant Physiology, 126 (2001) ; 849 –860
  • Pathogen derived elicitors: searching for receptors in plants.
    Author(s): Montesano, M. *, Brader, G. *, Palva, E.T. *equivalent work
    Journal: Mol. Plant Pathol. , 4 (2003) ; 73 - 79
  • The WRKY70 transcription factor: A node of convergence for jasmonate- and salicylate-mediated signals in plant defense.
    Author(s): Li, J., Brader, G., Palva E. T.
    Journal: Plant Cell, 16 (2004) ; 319-331
  • Chlorophyllase 1, a damage control enzyme, affects the balance between defense pathways in plants.
    Author(s): Kariola, T., Brader, G., Li, J, Palva, E. T.
    Journal: Plant Cell, 17 (2005) ; 282-294
  • Altering substrate chain length specificity of an acyl-homoserine lactone synthase in bacterial communication
    Author(s): Brader, G., Sjöblom, S., Hyytiäinen, H., Sims-Huopaniemi, K., Palva, E. T.
    Journal: J. Biol. Chem. , 280 (2005) ; 10403-10409
  • WRKY70 modulates the selection of signaling pathways in plant defense.
    Author(s): Li J, Brader G, Kariola T, Palva E. T.
    Journal: Plant J. , 46 (2006) ; 477-491
  • Altering glucosinolate profiles modulates disease resistance in plants.
    Author(s): Brader G., Mikkelsen M. D., Halkier B. A., Palva E.T.
    Journal: Plant J. , 46 (2006) ; 758-767
  • Cooperation of two distinct ExpR regulators controls quorum sensing specificity and virulence in the plant pathogen Erwinia carotovora.
    Author(s): Sjöblom S, Brader G, Koch G, Palva ET.
    Journal: Mol. Microbiol., 60 (2006) ; 1474-1489
  • Identifying functional gene sets from hierarchically clustered expression data: map of abiotic stress regulated genes in Arabidopsis thaliana.
    Author(s): Kankainen, M., Brader, G., Törönen, P., Palva, E.T., Holm, L.
    Journal: Nucl. Acid. Res. , 34 (2006) ; e124
  • EARLY RESPONSIVE TO DEHYDRATION 15 – a negative regulator of ABA-responses in Arabidopsis.
    Author(s): Kariola, T., Brader, G., Helenius, E., Li, J., Heino, P., Palva, E.T.
    Journal: Plant Physiol. , 142 (2006) ; 1559-1573
  • The Arabidopsis Mitogen-Activated Protein Kinase Kinase MKK3 Is Upstream of Group C Mitogen-Activated Protein Kinases and Participates in Pathogen Signaling.
    Author(s): Doczi, R., Brader, G., Pettko, S.A., Rajh, I., Djamei, A., Pitzschke, A., Teige, M., Hirt, H
    Journal: Plant Cell , 19 (2007) ; 3266-3279
  • Kunitz Trypsin Inhibitor: An Antagonist of Cell Death Triggered by Phytopathogens and Fumonisin B1 in Arabidopsis.
    Author(s): Li, J., Brader, G., Palva, E.T.
    Journal: Mol. Plant, 1 (2008) ; 482-495
  • Biotin Deficiency Causes Spontaneous Cell Death and Activation of Defense Signaling.
    Author(s): Li, J. *, Brader, G. *, Helenius, E., Kariola, T., Palva, E.T. *equivalent work
    Journal: Plant Journal , 70 (2012) ; 315–326
  • Use of beneficial bacteria and their secondary metabolites to control grapevine pathogen diseases.
    Author(s): Compant S.*, Brader G.*, Muzammil S.*, Sessitsch A., Lebrihi A., Mathieu F. (2013). *equivalent work
    Journal: BioControl, 58 (2013) ; 435-455
  • Advances in elucidating plant-soil-microbe (bacteria) interactions.
    Author(s): Mitter, B. *, Brader, G. *, Afzal, M., Compant, S., Naveed, M., Trognitz, F., Sessitsch, A. *equivalent work
    Journal: Adv. Agronomy, 121 (2013) ; 381-445
  • Metabolic potential of endophytic bacteria.
    Author(s): Brader, G., M., Compant, S., Mitter, B, Trognitz, F., Sessitsch, A.
    Journal: Curr. Opin. Biotechnol., 27 (2014) ; 30-37
  • An abundant Stolbur tuf b phytoplasma strain is associated with grapevine, stinging nettle and Hyalesthes obsoletus.
    Author(s): Aryan, A.*, Brader, G. *, Mörtel, J., Pastar, M., Riedle-Bauer, M. *equivalent work
    Journal: European Journal of Plant Pathology, 140 (2014) ; 213-227
  • Genome mining: prediction of lipopeptides and polyketides from Bacillus and related Firmicutes.
    Author(s): Aleti, G., Sessitsch, A., Brader, G.
    Journal: Computational and Structural Biotechnology Journal , 13 (2015) ; 192-203
  • Draft Genome Sequences of 10 Microbacterium spp., with Emphasis on Heavy Metal-Contaminated Environments.
    Author(s): Corretto, E., Antonielli, L., Sessitsch, A., Kidd, P., Weyens, N., Brader, G.
    Journal: Genome Announcements , 3 (2015) ; e00432-15
  • Chemical Genetics (2007)
    University of Helsinki
  • Structure and Function of Genomes. (2006)
    University of Helsinki
  • Pflanzliche Chemodiversität in den Paläotropen - Vielfalt bioaktiver Naturstoffe und deren ethnobotanische Bedeutung (2008)
    University of Vienna
  • Metabolomic profiling in plants and microbes (2008)
    “NOVA” nordic PhD course in plant pathology

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