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Molecular Imaging

Molecular imaging methods such as positron emission tomography (PET) supplies detailed images of disease processes at cellular level in the living organism. Combined with magnetic resonance tomography (MRT), PET provides unique insights into the molecular basis of diseases.

The targeted use of molecular imaging at key stages of drug development gives our customers a sound decision making basis for the further development process.

AIT has an interdisciplinary team of internationally renowned experts in molecular imaging. Our preclinical high-end research infrastructure and longstanding expertise in the planning and implementation of preclinical imaging studies makes us a reliable partner in both basic and applied research for the pharmaceuticals industry. Our established research network enables our customers rapid translation of preclinical results to clinical trials. 

 

Research Services

PET radiochemistry
Pre-clinical microPET and microMRT studies
Image analysis, dosimetry and modelling

Publications (Selection)

Mairinger, S., V. Zoufal, T. Wanek, A. Traxl, T. Filip, M. Sauberer, J. Stanek, C. Kuntner, J. Pahnke, M. Müller and O. Langer (2018). "Influence of breast cancer resistance protein and P-glycoprotein on tissue distribution and excretion of Ko143 assessed with PET imaging in mice." European Journal of Pharmaceutical Sciences 115: 212-222.

Heilemann, G., L. Fetty, M. Dulovits, M. Blaickner, N. Nesvacil, D. Georg and R. Dunavoelgyi (2017). "Treatment plan optimization and robustness of Ru-106 eye plaque brachytherapy using a novel software tool." Radiotherapy and Oncology 123(1): 119-124

Traxl, A., K. Komposch, E. Glitzner, T. Wanek, S. Mairinger, O. Langer and M. Sibilia (2017). "Hepatocyte-Specific Deletion of EGFR in Mice Reduces Hepatic Abcg2 Transport Activity Measured by [C-11]erlotinib and Positron Emission Tomography." Drug Metabolism and Disposition 45(10): 1093-1100.

Bauer, M., K. Römermann, R. Karch, B. Wulkersdorfer, J. Stanek, C. Philippe, A. Maier-Salamon, H. Haslacher, C. Jungbauer, W. Wadsak, W. Jäger, W. Löscher, M. Hacker, M. Zeitlinger and O. Langer (2016). "Pilot PET Study to Assess the Functional Interplay Between ABCB1 and ABCG2 at the Human Blood-Brain Barrier." Clinical Pharmacology & Therapeutics 100(2): 131-141.

Wanek, T., K. Kreis, P. Krizkova, A. Schweifer, C. Denk, J. Stanek, S. Mairinger, T. Filip, M. Sauberer, P. Edelhofer, A. Traxl, V. E. Muchitsch, K. Mereiter, F. Hammerschmidt, C. E. Cass, V. L. Damaraju, O. Langer and C. Kuntner (2016). "Synthesis and preclinical characterization of 1-(6 '-deoxy-6 '-[F-18]fluoro-beta-D-allofuranosyl)-2-nitroimidazole beta-6 '-[F-18]FAZAL) as a positron emission tomography radiotracer to assess tumor hypoxia." Bioorganic & Medicinal Chemistry 24(21): 5326-5339.

Denk, C., D. Svatunek, T. Filip, T. Wanek, D. Lumpi, J. Fröhlich, C. Kuntner and H. Mikula (2014). "Development of a F-18-Labeled Tetrazine with Favorable Pharmacokinetics for Bioorthogonal PET Imaging." Angewandte Chemie-International Edition 53(36): 9655-9659.

Complete List ...