Researcher Profile

Field: Molecular Diagnostics

Main Research: DNA-based Engineering and Sensing

Experience: Dr. Barisic has profound experience in the fields of biotechnology and clinical microbiology. He has developed several novel DNA detection principles and diagnostic assays. To enable a smooth translation of this basic research into future applications and identify customer needs, close collaborations with medical centres were established. As a consequence, Dr. Barisic has also become an expert concerning human pathogens, antibiotic resistance and virulence factors. He initiated the H2020 project FAPIC (www.fapic.eu) based on his novel detection technologies. The goal of FAPIC is to develop a single diagnostic test for all clinically important pathogens (bacteria, viruses and fungi), antibiotic resistance genes and virulence factors. The diagnostic system will be evaluated in a clinical intervention study in university hospitals in Zagreb and Hasselt. In addition, Dr. Barisic initiated and coordinates the H2020 FETopen project MARA (www.maraproject.eu). The goal of this highly ambitious project is to develop three radically novel breakthrough technologies. The first technology concerns a novel sensor class aiming the design of autonomous detection oligonucleotides. Second, a directed design concept for artificial enzymes using DNA nanostructures such as DNA origami is being evaluated. Finally, these technologies should be combined to generate a DNA robot that can specifically identify cells and destroy them.

• 2005-2007: Diploma student
  Department of Microbial Ecology DOME / Austria
• 2007-2008: Technical assistent
  Casa the los Tres Mundos / Nicaragua
• 2009-2013: PhD student
  AIT / Austria
• 2011-2011: Visiting scientist
  Uppsala University / Sweden
• 2013-2017: Scientist
  AIT / Austria
• 2018-now: Senior Scientist
  AIT / Austria

• High diversity of beta-lactamases in the General Hospital Vienna verified by whole genome sequencing and statistical analysis
  Author(s): Ivan Barišic, Dieter Mitteregger, Alexander M. Hirschl, Christa Noehammer, Herbert Wiesinger-Mayr
  Journal: Infection, Genetics and Evolution (2014)
• Fast and highly specific DNA-based multiplex detection on a solid support
  Author(s): Barišic I, Kamleithner V, Schönthaler S, Wiesinger-Mayr H
  Journal: Appl Microbiol Biotechnol (2015)
• Multiplex characterization of human pathogens including species and antibiotic-resistance gene identification
  Author(s): Barišic I, Petzka J, Schoenthaler S, Vierlinger K, Noehammer C, Wiesinger-Mayr H.
  Journal: J Med Microbiol (2016)
• (Poly)cation-induced protection of conventional and wireframe DNA origami nanostructures
  Author(s): Ahmadi Y, De Llano E, Barišic I
  Journal: Nanoscale (2018)
• Oli2go: an automated multiplex oligonucleotide design tool
  Author(s): M. Hendling, S. Pabinger, K. Peters, N. Wolff, R. Conzemius, I. Barisic
  Journal: Nucleic Acids Research (2018)

• FAST AND HIGHLY SPECIFIC DNA-BASED MULTIPLEX DETECTION
  Inventor: Ivan Barisic
  Submission Date: 23.09.2014
  Issue Date: 23.09.2014
• Autonomous sensing molecules
  Inventor: Ivan Barisic
  Submission Date: 27.11.2015
  Issue Date: 27.11.2015
• Nanostructures with catalytic activity
  Inventor: Ivan Barisic
  Submission Date: 27.11.2015
  Issue Date: 27.11.2015
• Molecular robot
  Inventor: Ivan Barisic
  Submission Date: 27.11.2015
  Issue Date: 27.11.2015

• Project homepage FAPIC
• Project homepage MARA
• Publications AIT publications database