Molecular Imaging

Molecular Imaging

Molecular imaging methods such as positron emission tomography (PET) supplies detailed images of disease processes at cellular level in the living organism. Combined with magnetic resonance tomography (MRT), PET provides unique insights into the molecular basis of diseases.

The targeted use of molecular imaging at key stages of drug development gives our customers a sound decision making basis for the further development process.

AIT has an interdisciplinary team of internationally renowned experts in molecular imaging. Our preclinical high-end research infrastructure and longstanding expertise in the planning and implementation of preclinical imaging studies makes us a reliable partner in both basic and applied research for the pharmaceuticals industry. Our established research network enables our customers rapid translation of preclinical results to clinical trials. 

Health & Environment Department

 

Research Services

PET radiochemistry
Pre-clinical microPET and microMRT studies
Image analysis, dosimetry and modelling

Publications

“Development of a (18)F-labeled tetrazine with favorable pharmacokinetics for bioorthogonal PET imaging”; Angew Chem Int Ed Engl. 2014;53:9655-9. http://www.ncbi.nlm.nih.gov/pubmed/24989029

 

“Guidance for methods descriptions used in preclinical imaging papers”;  Molecular imaging. 2013;12:1-15. http://www.ncbi.nlm.nih.gov/pubmed/23920252

 

“A novel PET protocol for visualization of breast cancer resistance protein function at the blood-brain barrier”; J Cereb Blood Flow Metab. 2012;32:2002-11.http://www.ncbi.nlm.nih.gov/pubmed/22828996

 

“PET and SPECT radiotracers to assess function and expression of ABC transporters in vivo”; Curr Drug Metab. 2011;12:774-92.http://www.ncbi.nlm.nih.gov/pubmed/21434859

 

“Gastric cancer growth control by BEZ235 in vivo does not correlate with PI3K/mTOR target inhibition but with [18F]FLT uptake”; Clin Cancer Res. 2011;17:5322-32http://www.ncbi.nlm.nih.gov/pubmed/21712451

 

“Targeted radionuclide therapy: theoretical study of the relationship between tumour control probability and tumour radius for a 32P/33P radionuclide cocktail”;Phys Med Biol. 2008;53:1961-74. http://www.ncbi.nlm.nih.gov/pubmed/18354241