The development and application of new materials and process technologies enables targeted improvement of material properties and the design and production of innovative implants. In this context, the AIS team collaborates closely with leading national and international research institutions and companies. Our research and development activities include both permanent and biodegradable metal-based implants.
Permanent implants require new materials with excellent biocompatibility and tailored properties in terms of strength, hardness, workability, longer service life and high patient comfort.
Novel biodegradable metallic materials for implants must combine highest biocompatibility, good mechanical properties and controllable degradation rates in the body. These biomaterials are designed for use in osteosynthesis systems and in vascular environments and offer the great advantage that they are absorbed by the body once they have fulfilled their function and thus do not need to be removed surgically.
These biodegradable metallic materials feature excellent biocompatibility in vivo, but specific in vitro cytocompatibility tests according to ISO standards are lacking. The existing ISO standard tests for metal implants are primarily designed for permanent metals. The new application-oriented 3D test setups provide a clearer picture of the processes within the organism and thus enable better prediction and planning of in vivo tests.
Application-oriented identification of suitable biomaterials and process technologies
Development and application of innovative and validatable process technologies (e.g. for the production of ultra-fine grained metallic biomaterials)
Degradation experiments on degradable metallic biomaterials and corrosion measurements on permanent implant materials
Equal Channel Angular Pressing ECAP of biomaterials (pure Mg, Mg alloys, pure Ti, Ti alloys) and non-biomaterials (electric Cu, Cu alloys, Al alloys) as a service for medical and non-medical applications.
Characterisation of mechanical properties such as hardness, compressive and tensile strength (including in simulated body fluids)
3D in vitro cytocompatibility tests for degradable metallic materials – in cooperation with partners
Consulting in regulatory issues according to MDD-2007 and quality management according to ISO 13485
Pre-clinical trials in cooperation with colleagues from the Molecular Imaging team
Excellent contacts to implant suppliers and manufacturers and to clinical partners
Longstanding experience in the acquisition and management of national and international funding projects in the field of advanced implant solutions.